sc2DAT

scRNA-seq 2 Drugs and Targets

Upload a single-cell or bulk RNA-seq expression matrix and select an appropriate single-cell reference to automatically identify cell types, discover cell-surface targets, and find LINCS L1000 compounds specific to those cell types.

Executed Reports:

Start with scRNA-seq data

Start with Bulk Data

Load bulk RNA-seq Example 1 (Lung Cancer)

Load bulk RNA-seq Example 2 (Pancreatic Cancer)

Condition Column:

Control Condition Name:

Single Cell Reference

N neighbors (2 - 100)

Min Distance (1e-05 - 0.9)

Resolution (0.1 - 2)

Species

Impute missing values

Predict doublets

Choose DepMap cell lines for target validation